Description
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.
Contributes to natural killer cell cytotoxicity.
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils.
Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400).
Alpha D beta 2, selectively binds ICAM-3 and does not appear to bind ICAM-1.
In addition, a soluble form of alpha D beta 2 binds VCAM-1 with greater efficiency relative to ICAM-3.
The I domain of alpha D contains a binding site for VCAM-1 since recombinant alpha D I domain binds specifically to VCAM-1